In October 2009, the world's population has been decimated by the spread of new strain of the Bubonic Plague which is resistant to antibiotics. One small group of survivors, led by Ruth Knight, is visited by a stranger who claims to possess a page from the Book of Destiny that foretells the future. To prove its accuracy he tells stories from the page of the Byzantine Empire during the Plague of Justinian (issue one), a princess at the beginning of the Black Death (issue two) and an Englishwoman during the Great Plague of London (issue three). Destiny himself is involved in each of the stories. The stranger then claims the page predicts the future of the current plague as well, and offers Ruth knowledge of her own destiny.