The stories in American Splendor concern the everyday life of Pekar in Cleveland, Ohio. Situations covered include Pekar''s job as a file clerk at a Veteran''s Administration hospital and his relations with work colleagues and patients there. There are also stories about Pekar and his relations with friends and family, including his third wife Joyce Brabner and their adopted daughter Danielle. Other stories concern everyday situations such as Pekar''s troubles with his car, money, his health, and his concerns and anxieties in general.